The practice for holistic internal medicine has been run since 2002 by internist and nephrologist Dr. med. Helena Orfanos-Boeckel (since 2018 as a private practice). The main focus is on holistic internal therapy using nutrients and hormones, as published by Dr. Orfanos-Boeckel in her books. A key priority for Dr. Orfanos-Boeckel is the early, thorough, and functional use of laboratory diagnostics to identify individual metabolic weaknesses, treat them specifically, and thereby prevent the consequences of age-related metabolic diseases.